Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105924
Title: Factors associated with false-positive mammography at first screen in an Asian population
Authors: Ho, Peh Joo
Bok, Chek Mei
Lim, Li Yan
Liu, Jenny
Wong, Fuh Yong
Chia, Kee Seng
Tan, Min-Han
Chay, Wen Yee
Hartman, Mikael
Li, Jingmei
Hanis Mariyah Mohd Ishak
Keywords: Mammography
DRNTU::Science::Biological sciences
Breast Cancer
Issue Date: 2019
Source: Ho, P. J., Bok, C. M., Hanis Mariyah Mohd Ishak, Lim, L. Y., Liu, J., Wong, F. Y., . . . Li, J. (2019). Factors associated with false-positive mammography at first screen in an Asian population. PLOS ONE, 14(3), e0213615-. doi:10.1371/journal.pone.0213615
Series/Report no.: PLOS ONE
Abstract: Introduction : False-positive recall is an issue in national screening programmes. The aim of this study is to investigate the recall rate at first screen and to identify potential predictors of false-positive recall in a multi-ethnic Asian population-based breast cancer screening programme. Methods : Women aged 50–64 years attending screening mammography for the first time (n = 25,318) were included in this study. The associations between potential predictors (sociodemographic, lifestyle and reproductive) and false-positive recall were evaluated using multivariable logistic regression models. Results : The recall rate was 7.6% (n = 1,923), of which with 93.8% were false-positive. Factors independently associated with higher false-positive recall included Indian ethnicity (odds ratio [95% confidence interval]: 1.52 [1.25 to 1.84]), premenopause (1.23 [1.04 to 1.44]), nulliparity (1.85 [1.57 to 2.17]), recent breast symptoms (1.72 [1.31 to 2.23]) and history of breast lump excision (1.87 [1.53 to 2.26]). Factors associated with lower risk of false-positive recall included older age at screen (0.84 [0.73 to 0.97]) and use of oral contraceptives (0.87 [0.78 to 0.97]). After further adjustment of percent mammographic density, associations with older age at screening (0.97 [0.84 to 1.11]) and menopausal status (1.12 [0.95 to 1.32]) were attenuated and no longer significant. Conclusion : For every breast cancer identified, 15 women without cancer were subjected to further testing. Efforts to educate Asian women on what it means to be recalled will be useful in reducing unnecessary stress and anxiety.
URI: https://hdl.handle.net/10356/105924
http://hdl.handle.net/10220/48839
DOI: 10.1371/journal.pone.0213615
Rights: © 2019 Ho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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