Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/105981
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dc.contributor.authorFaheem Ahmed Khanen
dc.contributor.authorChua, Mui Tengen
dc.contributor.authorNg, Wei Mingen
dc.contributor.authorLu, Qingshuen
dc.contributor.authorLow, Matthew Jian Wenen
dc.contributor.authorYau, Ying Weien
dc.contributor.authorPunyadasa, Amilaen
dc.contributor.authorKuan, Win Senen
dc.date.accessioned2019-06-19T03:25:51Zen
dc.date.accessioned2019-12-06T22:02:08Z-
dc.date.available2019-06-19T03:25:51Zen
dc.date.available2019-12-06T22:02:08Z-
dc.date.issued2019en
dc.identifier.citationChua, M. T., Faheem Ahmed Khan, Ng, W. M., Lu, Q., Low, M. J. W., Yau, Y. W., . . . Kuan, W. S. (2019). Pre- and apnoeic high flow oxygenation for RApid sequence intubation in the emergency department (pre-AeRATE) : study protocol for a multicentre, randomised controlled trial. Trials, 20, 195-. doi:10.1186/s13063-019-3305-8en
dc.identifier.urihttps://hdl.handle.net/10356/105981-
dc.description.abstractBackground : Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current best practices during RSI, desaturation during intubation still occurs. High-flow nasal cannula (HFNC) oxygenation may potentially improve oxygenation during pre- and apnoeic oxygenation to allow a longer safe apnoeic time for RSI. Objective : We aim to test the hypothesis that the use of humidified high-flow oxygenation via nasal cannula at 60 L/min maintains higher oxygen saturation compared with current usual care of non-rebreather mask and standard nasal cannula at an oxygen flow rate of 15L/min for pre- and apnoeic oxygenation. Methods : This is a multi-centre randomised controlled trial enrolling adult patients aged 21 years and older who require rapid sequence intubation due to medical, surgical, or traumatic conditions in the Emergency Departments (EDs) of the National University Hospital and the Ng Teng Fong General Hospital. Eligible patients will undergo randomisation at an equal ratio into intervention or control arms. The primary endpoint will be the lowest oxygen saturation achieved during the first intubation attempt from time of administration of paralytic agent until quantitative end-tidal carbon dioxide is detected if the first intubation attempt is successful, or until the start of the second attempt if it is not. Discussion : Prolongation of safe apnoea time through maintenance of oxygen saturation above 90% using HFNC oxygenation during RSI could potentially change current clinical practice, improve standard of care, and translate to better outcomes for patients.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent9 p.en
dc.language.isoenen
dc.relation.ispartofseriesTrialsen
dc.rights© 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectRapid Sequence Intubationen
dc.subjectHigh Flow Nasal Oxygenationen
dc.subjectDRNTU::Science::Medicineen
dc.titlePre- and apnoeic high flow oxygenation for RApid sequence intubation in the emergency department (pre-AeRATE) : study protocol for a multicentre, randomised controlled trialen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.1186/s13063-019-3305-8en
dc.description.versionPublished versionen
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item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles

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