Please use this identifier to cite or link to this item:
|Title:||Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy||Authors:||Cui, Yujie
Srinivasan, Dinesh Kumar
|Keywords:||DRNTU::Science::Medicine||Issue Date:||2012||Source:||Cui, Y., Wang, W., Dong, N., Lou, J., Srinivasan, D. K., Cheng, W., Huang, X., Liu, M., Fang, C., Peng, J., Chen, S., Wu, S., Liu, Z., Dong, L., Zhou, Y.,& Wu, Q. (2012). Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature, 484(7393), 246-250.||Series/Report no.:||Nature||Abstract:||In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear1, 2. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure3. Unexpectedly, corin expression was detected in the pregnant uterus4. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterine Corin messenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identified Corin gene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal–fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.||URI:||https://hdl.handle.net/10356/106141
|ISSN:||0028-0836||DOI:||10.1038/nature10897||Rights:||© 2012 Nature Publishing Group.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.