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https://hdl.handle.net/10356/106141
Title: | Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy | Authors: | Cui, Yujie Wang, Wei Dong, Ningzheng Lou, Jinglei Srinivasan, Dinesh Kumar Cheng, Weiwei Huang, Xiaoyi Liu, Meng Fang, Chaodong Peng, Jianhao Chen, Shenghan Wu, Shannon Liu, Zhenzhen Dong, Liang Zhou, Yiqing Wu, Qingyu |
Keywords: | DRNTU::Science::Medicine | Issue Date: | 2012 | Source: | Cui, Y., Wang, W., Dong, N., Lou, J., Srinivasan, D. K., Cheng, W., Huang, X., Liu, M., Fang, C., Peng, J., Chen, S., Wu, S., Liu, Z., Dong, L., Zhou, Y.,& Wu, Q. (2012). Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature, 484(7393), 246-250. | Series/Report no.: | Nature | Abstract: | In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear1, 2. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure3. Unexpectedly, corin expression was detected in the pregnant uterus4. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterine Corin messenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identified Corin gene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal–fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia. | URI: | https://hdl.handle.net/10356/106141 http://hdl.handle.net/10220/23962 |
ISSN: | 0028-0836 | DOI: | 10.1038/nature10897 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2012 Nature Publishing Group. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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