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Title: Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy
Authors: Cui, Yujie
Wang, Wei
Dong, Ningzheng
Lou, Jinglei
Srinivasan, Dinesh Kumar
Cheng, Weiwei
Huang, Xiaoyi
Liu, Meng
Fang, Chaodong
Peng, Jianhao
Chen, Shenghan
Wu, Shannon
Liu, Zhenzhen
Dong, Liang
Zhou, Yiqing
Wu, Qingyu
Keywords: DRNTU::Science::Medicine
Issue Date: 2012
Source: Cui, Y., Wang, W., Dong, N., Lou, J., Srinivasan, D. K., Cheng, W., Huang, X., Liu, M., Fang, C., Peng, J., Chen, S., Wu, S., Liu, Z., Dong, L., Zhou, Y.,& Wu, Q. (2012). Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature, 484(7393), 246-250.
Series/Report no.: Nature
Abstract: In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear1, 2. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure3. Unexpectedly, corin expression was detected in the pregnant uterus4. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterine Corin messenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identified Corin gene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal–fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.
ISSN: 0028-0836
DOI: 10.1038/nature10897
Rights: © 2012 Nature Publishing Group.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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