Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106244
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dc.contributor.authorGinhoux, Florenten
dc.contributor.authorSu, I-hsinen
dc.contributor.authorGunawan, Merryen
dc.contributor.authorVenkatesan, Nandinien
dc.contributor.authorLoh, Jia Tongen
dc.contributor.authorWong, Jong Fuen
dc.contributor.authorBerger, Heidien
dc.contributor.authorNeo, Wen Haoen
dc.contributor.authorLi, Liang Yao Jacksonen
dc.contributor.authorLa Win, Myint Khunen
dc.contributor.authorYau, Yin Hoeen
dc.contributor.authorGuo, Tiannanen
dc.contributor.authorSee, Peter Chi Eeen
dc.contributor.authorYamazaki, Sayurien
dc.contributor.authorChin, Keh Chuangen
dc.contributor.authorGingras, Alexandre R.en
dc.contributor.authorShochat, Susana Geifmanen
dc.contributor.authorNg, Lai Guanen
dc.contributor.authorSze, Siu Kwanen
dc.date.accessioned2015-07-13T11:51:13Zen
dc.date.accessioned2019-12-06T22:07:17Z-
dc.date.available2015-07-13T11:51:13Zen
dc.date.available2019-12-06T22:07:17Z-
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationGunawan, M., Venkatesan, N., Loh, J. T., Wong, J. F., Berger, H., Neo, W. H., et al. (2015). The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nature Immunology, 16(5), 505-516.en
dc.identifier.urihttps://hdl.handle.net/10356/106244-
dc.description.abstractA cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation has been suggested, but the molecular mechanisms underpinning this extranuclear function have remained unclear. Here we found that Ezh2 regulated the integrin signaling and adhesion dynamics of neutrophils and dendritic cells (DCs). Ezh2 deficiency impaired the integrin-dependent transendothelial migration of innate leukocytes and restricted disease progression in an animal model of multiple sclerosis. Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures. This regulatory effect was abolished by targeted disruption of the interactions of Ezh2 with the cytoskeletal-reorganization effector Vav1. Our studies reveal an unforeseen extranuclear function for Ezh2 in regulating adhesion dynamics, with implications for leukocyte migration, immune responses and potentially pathogenic processes.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.language.isoenen
dc.relation.ispartofseriesNature immunologyen
dc.rights© 2015 Nature America, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature Immunology, Nature America, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1038/ni.3125].en
dc.subjectDRNTU::Science::Biological sciences::Microbiology::Immunologyen
dc.titleThe methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talinen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1038/ni.3125en
dc.description.versionAccepted versionen
item.fulltextWith Fulltext-
item.grantfulltextopen-
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