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Title: Dissolvable polyvinyl-alcohol film, a time-barrier to modulate sample flow in a 3d-printed holder for capillary flow paper diagnostics
Authors: Yitian, Alicia Lu
Eltzov, Evgeni
Marks, Robert S.
Tok, Alfred Iing Yoong
Harpaz, Dorin
Axelrod, Tim
Keywords: DRNTU::Engineering::Materials
Polyvinyl Alcohol
Dissolvable Membrane
Issue Date: 2019
Source: Harpaz, D., Axelrod, T., Yitian, A. L., Eltzov, E., Marks, R. S., & Tok, A. I. Y. (2019). Dissolvable Polyvinyl-Alcohol Film, a Time-Barrier to Modulate Sample Flow in a 3D-Printed Holder for Capillary Flow Paper Diagnostics. Materials, 12(3), 343-. doi:10.3390/ma12030343
Series/Report no.: Materials
Abstract: Integrating a dissolvable membrane into a sensor allows the control of sample flow, location and duration in critical areas. These time-barrier films stop the flow of samples until the membrane has dissolved, thus, for example, allowing increased exposure time between immunoreagents for the formation of greater numbers of immuno-complexes, ensuring higher sensitivity, reactivity, and helping to reduce false-positive signals. In this study, dissolvable polyvinyl alcohol (PVA) films are used in a 3D-printed sensor holder, which enables film integration without the use of glue. PVA is a synthetic hydrophilic linear polymer, its solubility is dependent on its molecular weight and degree of hydrolysis. Three types of PVAs films were tested herein: (1) PVA 1-Mw: 30–70 K, 87–90% hydrolyzed; (2) PVA 2-Mw: 31–50 K, 98–99% hydrolyzed and (3) PVA 3-Mw: 89–98 K, >99% hydrolyzed. The films were exposed to water in (1) the novel 3D-printed holder and (2) directly immersed into a water droplet. After comparing the time taken to dissolve PVA 1–3 films, PVA 1 films of 5–20% (w/v) are found to be most suitable as time barrier films, due to their optimal dissolution times and physical properties for integration into the customized 3D-printed holder.
ISSN: 1996-1944
DOI: 10.3390/ma12030343
Rights: © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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