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|Title:||Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes||Authors:||Chee, Soon Phaik
Cheung, Chui Ming Gemmy
Wong, Tina T.
|Keywords:||DRNTU::Engineering::Materials||Issue Date:||2012||Source:||Chua, J., Vania, M., Cheung, C. M. G., Ang, M., Chee, S. P., Yang, H., et al. (2012). Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Molecular vision, 18, 431-438.||Series/Report no.:||Molecular vision||Abstract:||PURPOSE: To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes. METHODS: Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 medically treated glaucoma patients and 23 cataract subjects recruited in an institutional setting in this case-controlled study. The main outcome measure was to quantify the levels of 29 inflammatory cytokines in the aqueous of glaucoma and cataract subjects using a multiplexed cytokine analysis. Data on patient demographics, duration of glaucoma, preoperative intraocular pressure (IOP) as well as duration of anti-glaucoma therapy were also collected for correlation analysis. RESULTS: Mean duration of glaucoma was 53.8 months (range 1-360 months). Aqueous obtained from the glaucoma patients showed increased concentration of interleukin (IL)-9 (p=0.032), IL-12 (p=0.003), interferon (IFN)-α (p=0.034), IFN-γ (p=0.002), monokine induced by interferon-gamma (MIG or CXCL9) (p=0.006), and IL-10 (p=0.050), compared to the cataract group. The POAG group had higher IL-12 (p=0.011), IFN-γ (p=0.005), and CXCL9 (p=0.047) levels than controls, while the PACG group had higher interleukin-8 (CXCL8) (p=0.015) and CXCL9 (p=0.023) levels than the controls. No significant correlation was observed between aqueous cytokine level and preoperative IOP and duration of glaucoma. Duration of topical Timolol and Alphagan therapy correlated negatively with CXCL8 (r=-0.588, p=0.035), respectively. CONCLUSIONS: Primary glaucoma is associated with an aqueous inflammatory response and this is different between POAG and PACG groups. Duration of glaucoma treatment may have an effect on cytokine profile in the aqueous.||URI:||https://hdl.handle.net/10356/106285
|URL:||http://www.ncbi.nlm.nih.gov/pubmed/22355254||ISSN:||1090-0535||Rights:||© 2012 The Author(s). This paper was published in Molecular Vision and is made available as an electronic reprint (preprint) with permission of the Author(s). The paper can be found at the following official URL: http://www.ncbi.nlm.nih.gov/pubmed/22355254. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
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