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dc.contributor.authorChen, Tian Ningen
dc.contributor.authorLiu, Ai Qunen
dc.contributor.authorChin, Lip Keten
dc.contributor.authorWu, Jiu Huien
dc.contributor.authorShi, Yu Zhien
dc.contributor.authorSha, Xiongen
dc.contributor.authorZhang, Yien
dc.contributor.editorDholakia, Kishanen
dc.contributor.editorSpalding, Gabriel C.en
dc.identifier.citationShi, Y. Z., Xiong, S., Zhang, Y., Chin, L. K., Wu, J. H., Chen, T. N., & Liu, A. Q. (2017). Sorting and measurement of single gold nanoparticles in an optofluidic chip. Proceedings of SPIE - Optical Trapping and Optical Micromanipulation XIV, 10347, 1034738-. doi:10.1117/12.2272114en
dc.description.abstractGold nanoparticles have sparked strong interest owing to their unique optical and chemical properties. Their sizedependent refractive index and plasmon resonance are widely used for optical sorting, biomedicine and chemical sensing. However, there are only few examples of optical separation of different gold nanoparticles. Only separating 100-200 nm gold nanoparticles using wavelength selected resonance of the extinction spectrum has been demonstrated. This paper reports an optofluidic chip for sorting single gold nanoparticles using loosely overdamped optical potential wells, which are created by building optical and fluidic barriers. It is the first demonstration of sorting single nanoparticles with diameters ranging from 60 to 100 nm in a quasi-Bessel beam with an optical trapping stiffness from 10−10 to 10−9 N/m. The nanoparticles oscillate in the loosely overdamped potential wells with a displacement amplitude of 3–7 μm in the microchannel. The sizes and refractive indices of the nanoparticles can be determined from their trapping positions using Drude and Mie theory, with a resolution of 0.35 nm/μm for the diameter, 0.0034/μm and 0.0017/μm for the real and imaginary parts of the refractive index, respectively. Here we experimentally demonstrate the sorting of bacteria and protozoa on the optofluidic chip. The chip has high potential for the sorting and characterization of nanoparticles in biomedical applications such as tumour targeting, drug delivery and intracellular imaging.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.format.extent5 p.en
dc.relation.ispartofseriesProceedings of SPIE - Optical Trapping and Optical Micromanipulation XIVen
dc.rights© 2017 SPIE. All rights reserved. This paper was published in Proceedings of SPIE - Optical Trapping and Optical Micromanipulation XIV and is made available with permission of SPIE.en
dc.subjectOptical Sortingen
dc.subjectEngineering::Electrical and electronic engineeringen
dc.subjectGold Nanoparticleen
dc.titleSorting and measurement of single gold nanoparticles in an optofluidic chipen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
dc.contributor.conferenceOptical Trapping and Optical Micromanipulation XIVen
dc.description.versionPublished versionen
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