Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106551
Title: Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency
Authors: Zhu, Mengxiang
Wang, Yingying
Ferracci, Gaia
Zheng, Jing
Cho, Nam-Joon
Lee, Bae Hoon
Keywords: Biomaterials
Biomaterials-proteins
DRNTU::Engineering::Materials
Issue Date: 2019
Source: Zhu, M., Wang, Y., Ferracci, G., Zheng, J., Cho, N.-J., & Lee, B. H. (2019). Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency. Scientific Reports, 9(1), 6863-. doi:10.1038/s41598-019-42186-x
Series/Report no.: Scientific Reports
Abstract: Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy.
URI: https://hdl.handle.net/10356/106551
http://hdl.handle.net/10220/48948
DOI: 10.1038/s41598-019-42186-x
Rights: © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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