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dc.contributor.authorZhu, Mengxiangen
dc.contributor.authorWang, Yingyingen
dc.contributor.authorFerracci, Gaiaen
dc.contributor.authorZheng, Jingen
dc.contributor.authorCho, Nam-Joonen
dc.contributor.authorLee, Bae Hoonen
dc.identifier.citationZhu, M., Wang, Y., Ferracci, G., Zheng, J., Cho, N.-J., & Lee, B. H. (2019). Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency. Scientific Reports, 9(1), 6863-. doi:10.1038/s41598-019-42186-xen
dc.description.abstractGelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy.en
dc.format.extent13 p.en
dc.relation.ispartofseriesScientific Reportsen
dc.rights© 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.titleGelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistencyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.description.versionPublished versionen
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