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Title: Maternal separation does not produce a significant behavioral change in mice
Authors: Tan, Shawn
Ho, Hin San
Song, Anna Yoonsu
Low, Joey
Je, Shawn Hyunsoo
Keywords: Maternal Separation
DRNTU::Science::Biological sciences
Early-life Stress
Issue Date: 2017
Source: Tan, S., Ho, H. S., Song, A. Y., Low, J., & Je, S. H. (2017). Maternal separation does not produce a significant behavioral change in mice. Experimental Neurobiology, 26(6), 390-398. doi:10.5607/en.2017.26.6.390
Series/Report no.: Experimental Neurobiology
Abstract: Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification.
ISSN: 1226-2560
DOI: 10.5607/en.2017.26.6.390
Rights: © 2017 Experimental Neurobiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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