Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106582
Title: A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug
Authors: Zhao, Yang
Luo, Zhong
Li, Menghuan
Qu, Qiuyu
Ma, Xing
Yu, Shu-Hong
Zhao, Yanli
Keywords: DRNTU::Engineering::Materials::Nanostructured materials
Issue Date: 2015
Source: Zhao, Y., Luo, Z., Li, M., Qu, Q., Ma, X., Yu, S.-H., et al. (2015). A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug. Angewandte chemie International edition, 54(3), 919-922.
Series/Report no.: Angewandte chemie International edition
Abstract: Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH-responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy.
URI: https://hdl.handle.net/10356/106582
http://hdl.handle.net/10220/25002
ISSN: 1433-7851
DOI: 10.1002/anie.201408510
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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