Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106624
Title: Sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium from electrospun polycaprolactone scaffold : a study across blend, coaxial, and emulsion electrospinning techniques
Authors: Zhao, Xinxin
Lui, Siang Yuan
Toh, Pei Wen Jessica
Loo, Say Chye Joachim
Keywords: DRNTU::Engineering::Materials::Ecomaterials
Issue Date: 2014
Source: Zhao, X., Lui, Y. S., Toh, P. W. J., & Loo, S. Y. J. (2014). Sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium from electrospun polycaprolactone scaffold : a study across blend, coaxial, and emulsion electrospinning techniques. Materials, 7(11), 7398-7408.
Series/Report no.: Materials
Abstract: The purpose of this study was to achieve a sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium (ASP) from electrospun polycaprolactone (PCL) scaffolds, so as to promote the osteogenic differentiation of stem cells for bone tissue engineering (TE). ASP was loaded and electrospun together with PCL via three electrospinning techniques, i.e., coaxial, emulsion, and blend electrospinning. For blend electrospinning, binary solvent systems of dichloromethane–methanol (DCM–MeOH) and dichloromethane–dimethylformamide (DCM–DMF) were used to achieve the desired ASP release through the effect of solvent polarity and volatility. The scaffold prepared via a blend electrospinning technique with a binary solvent system of DCM–MeOH at a 7:3 ratio demonstrated a desirable, sustained ASP release profile for as long as two weeks, with minimal burst release. However, an undesirable burst release (~100%) was observed within the first 24 h for scaffolds prepared by coaxial electrospinning. Scaffolds prepared by emulsion electrospinning displayed poorer mechanical properties. Sustained releasing blend electrospun scaffold could be a good potential candidate as an ASP-eluting scaffold for bone tissue engineering.
URI: https://hdl.handle.net/10356/106624
http://hdl.handle.net/10220/25044
ISSN: 1996-1944
DOI: 10.3390/ma7117398
Rights: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
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