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Title: Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
Authors: Lin, Guimiao
Wang, Xiaomei
Yin, Feng
Yong, Ken-Tye
Keywords: DRNTU::Science::Medicine
Issue Date: 2015
Source: Lin, G., Wang, X., Yin, F., & Yong, K.-T. (2015). Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots. International journal of nanomedicine, 10, 335-345.
Series/Report no.: International journal of nanomedicine
Abstract: In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high as ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors.
ISSN: 1178-2013
DOI: 10.2147/IJN.S74805
Rights: © 2015 Lin et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
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