Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106839
Title: Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides
Authors: Jackman, Joshua A.
Saravanan, Rathi
Zhang, Yibang
Tabaei, Seyed R.
Cho, Nam-Joon
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2015
Source: Jackman, J. A., Saravanan, R., Zhang, Y., Tabaei, S. R., & Cho, N.-J. (2015). Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides. Small, 11(20), 2372-2379.
Series/Report no.: Small
Abstract: The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.
URI: https://hdl.handle.net/10356/106839
http://hdl.handle.net/10220/25155
ISSN: 1613-6810
DOI: 10.1002/smll.201403638
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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