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|Title:||Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides||Authors:||Jackman, Joshua A.
Tabaei, Seyed R.
|Keywords:||DRNTU::Science::Medicine::Biomedical engineering||Issue Date:||2015||Source:||Jackman, J. A., Saravanan, R., Zhang, Y., Tabaei, S. R., & Cho, N.-J. (2015). Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides. Small, 11(20), 2372-2379.||Series/Report no.:||Small||Abstract:||The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.||URI:||https://hdl.handle.net/10356/106839
|ISSN:||1613-6810||DOI:||10.1002/smll.201403638||Rights:||© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||MSE Journal Articles|
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