Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106843
Title: Metabolomic profiling of rhodosporidium toruloides grown on glycerol for carotenoid production during different growth phases
Authors: Lee, Jaslyn Jie Lin
Chen, Liwei
Shi, Jiahua
Trzcinski, Antoine
Chen, Wei Ning
Keywords: DRNTU::Engineering::Environmental engineering
Issue Date: 2014
Source: Lee, J. J. L., Chen, L., Shi, J., Trzcinski, A., & Chen, W.-N. (2014). Metabolomic profiling of rhodosporidium toruloides grown on glycerol for carotenoid production during different growth phases. Journal of agricultural and food chemistry, 62(41), 10203-10209.
Series/Report no.: Journal of agricultural and food chemistry
Abstract: Carotenoid production from three strains of Rhodosporidium toruloides grown on glycerol was studied. A time-dependent metabolomics approach was used to understand its metabolism on glycerol and mechanism for carotenoid production in three strains during different growth phases (1, 4, 7, and 12 days). Strain CBS 5490 was the highest carotenoid producer (28.5 mg/L) and had a unique metabolic profile. In this strain, metabolites belonging to the TCA cycle and amino acids were produced in lower amounts, as compared to the other strains. On the other hand, it produced the highest amounts of carotenoid and fatty acid metabolites. This indicated that the lower production of the TCA cycle and amino acid metabolites promoted energy and metabolic flux toward the carotenoid and fatty acid synthesis metabolic pathways. This study shows that metabolomic profiling is a useful tool to gain insight into the metabolic pathways in the cell and to shed light on the different molecular mechanisms between strains.
URI: https://hdl.handle.net/10356/106843
http://hdl.handle.net/10220/25205
DOI: 10.1021/jf502987q
Schools: School of Chemical and Biomedical Engineering 
School of Civil and Environmental Engineering 
Research Centres: Nanyang Environment and Water Research Institute 
Rights: © 2014 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Agricultural and Food Chemistry, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/jf502987q].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CEE Journal Articles
NEWRI Journal Articles
SCBE Journal Articles

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