Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106877
Title: Pd-catalyzed enantiodivergent and regiospecific phospha-michael addition of diphenylphosphine to 4-oxo-enamides : efficient access to chiral phosphinocarboxamides and their analogues
Authors: Chew, Renta Jonathan
Li, Xi-Rui
Li, Yongxin
Pullarkat, Appukuttan Sumod
Leung, Pak-Hing
Keywords: DRNTU::Science::Chemistry
Issue Date: 2015
Source: Chew, R. J., Li, X.-R., Li, Y., Pullarkat, S. A., & Leung, P.-H. (2015). Pd-catalyzed enantiodivergent and regiospecific phospha-michael addition of diphenylphosphine to 4-oxo-enamides : efficient access to chiral phosphinocarboxamides and their analogues. Chemistry - A European journal, 21(12), 4800-4804 .
Series/Report no.: Chemistry - A European journal
Abstract: The palladacycle-catalyzed asymmetric P-H addition of 4-oxo-enamides has been developed, which provides efficient access to phosphinocarboxamides and their analogues. Solvent-mediated reversal of stereoselectivity (ee from +96 % to −92 %) was observed, and the underlying mechanism that allows facile access to both enantiomers of the product by judicious choice of solvents is revealed.
URI: https://hdl.handle.net/10356/106877
http://hdl.handle.net/10220/25190
ISSN: 0947-6539
DOI: 10.1002/chem.201406298
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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