Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106985
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dc.contributor.authorEro, Ryaen
dc.contributor.authorDimitrova, Valya Tenushevaen
dc.contributor.authorChen, Yunen
dc.contributor.authorBu, Wentingen
dc.contributor.authorFeng, Shuen
dc.contributor.authorLiu, Tongbaoen
dc.contributor.authorWang, Pingen
dc.contributor.authorXue, Chaoyangen
dc.contributor.authorTan, Suet Mienen
dc.contributor.authorGao, Yong-Guien
dc.date.accessioned2015-03-24T07:42:15Zen
dc.date.accessioned2019-12-06T22:22:27Z-
dc.date.available2015-03-24T07:42:15Zen
dc.date.available2019-12-06T22:22:27Z-
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationEro, R., Dimitrova, V. T., Chen, Y., Bu, W., Feng, S., Liu, T., et al. (2015). Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans. Scientific reports, 5, 8688-.en
dc.identifier.issn2045-2322en
dc.identifier.urihttps://hdl.handle.net/10356/106985-
dc.description.abstractThe atypical Gβ-like/RACK1 Gib2 protein promotes cAMP signalling that plays a central role in regulating the virulence of Cryptococcus neoformans. Gib2 contains a seven-bladed β transducin structure and is emerging as a scaffold protein interconnecting signalling pathways through interactions with various protein partners. Here, we present the crystal structure of Gib2 at a 2.2-Å resolution. The structure allows us to analyse the association between Gib2 and the ribosome, as well as to identify the Gib2 amino acid residues involved in ribosome binding. Our studies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical link at the crossroads of various regulatory pathways important for the growth and virulence of C. neoformans.en
dc.format.extent11 p.en
dc.language.isoenen
dc.relation.ispartofseriesScientific reportsen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleCrystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformansen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1038/srep08688en
dc.description.versionPublished versionen
dc.identifier.pmid25732347-
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