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Title: Real-time measurement of single bacterium's refractive index using optofluidic immersion refractometry
Authors: Liu, P. Y.
Chin, Lip Ket
Ser, Wee
Ayi, T. C.
Yap, P. H.
Bourouina, T.
Leprince-Wang, Y.
Keywords: DRNTU::Science::Biological sciences::Biophysics
Issue Date: 2014
Source: Liu, P. Y., Chin, L. K., Ser, W., Ayi, T. C., Yap, P. H., Bourouina, T., et al. (2014). Real-time measurement of single bacterium's refractive index using optofluidic immersion refractometry. Procedia engineering, 87, 356-359.
Series/Report no.: Procedia Engineering
Conference: EUROSENSORS the European Conference on Solid-State Transducers (28th : 2014)
Abstract: This paper presents a biophysical method to characterize single bacterium in water by using an on-chip optofluidic immersion refractometer. Water safety is a major factor in the well-being of people, but the presence of bacteria such as Escherichia coli (E. coli), bacillus subtilis, Shigella flexneri and vibrio cholera in drinking water can lead to infectious diseases such as typhoid fever. Hence, it is crucial to detect and identify bacteria to prevent bacterial outbreaks. In this paper, an optofluidic immersion refractometer is developed to measure three biophysical parameters, i.e. size, shape and refractive index. The refractive index of a single bacterium is measured in high sensitivity of 0.005 RIU. This system is an innovative method to allow on-site real-time detection of single bacterium in water. It significantly reduces the amount of detection time and do not require trained personnel or additional chemical and biological reagents.
DOI: 10.1016/j.proeng.2014.11.743
Schools: School of Electrical and Electronic Engineering 
Rights: © 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Conference Papers

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