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Title: Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents
Authors: Ang, Hui Ying
Huang, Ying Ying
Lim, Soo Teik
Wong, Philip
Joner, Michael
Foin, Nicolas
Keywords: Coronary Artery Disease
Bioresorbable Stents
Issue Date: 2017
Source: Ang, H. Y., Huang, Y. Y., Lim, S. T., Wong, P., Joner, M., & Foin, N. (2017). Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents. Journal of Thoracic Disease, 9(S9), S923-S934. doi:10.21037/jtd.2017.06.30
Series/Report no.: Journal of Thoracic Disease
Abstract: Bioresorbable scaffolds (BRS) were developed to overcome the drawbacks of current metallic drug-eluting stents (DES), such as late in-stent restenosis and caging of the vessel permanently. The concept of the BRS is to provide transient support to the vessel during healing before being degraded and resorbed by the body, freeing the vessel and restoring vasomotion. The mechanical properties of the BRS are influenced by the choice of the material and processing methods. Due to insufficient radial strength of the bioresorbable material, BRS often required large strut profile as compared to conventional metallic DES. Having thick struts will in turn affect the deliverability of the device and may cause flow disturbance, thereby increasing the incidence of acute thrombotic events. Currently, the bioresorbable poly-l-lactic acid (PLLA) polymer and magnesium (Mg) alloys are being investigated as materials in BRS technologies. The bioresorption process, mechanical properties, in vitro observations and clinical outcomes of PLLA-based and Mg-based BRS will be examined in this review.
ISSN: 2072-1439
DOI: 10.21037/jtd.2017.06.30
Schools: School of Materials Science & Engineering 
Rights: © 2017 Journal of Thoracic Disease. All rights reserved. This paper was published in Journal of Thoracic Disease and is made available with permission of Journal of Thoracic Disease.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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