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Title: Alternative configuration scheme for signal amplification with scanning ion conductance microscopy
Authors: Kim, Joonhui
Kim, Seong-Oh
Cho, Nam-Joon
Keywords: DRNTU::Engineering::Materials::Compositional materials science
Issue Date: 2015
Source: Kim, J., Kim, S.-O., & Cho, N.-J. (2015). Alternative configuration scheme for signal amplification with scanning ion conductance microscopy. Review of scientific instruments, 86(2), 023706-.
Series/Report no.: Review of scientific instruments
Abstract: Scanning Ion Conductance Microscopy (SICM) is an emerging nanotechnology tool to investigate the morphology and charge transport properties of nanomaterials, including soft matter. SICM uses an electrolyte filled nanopipette as a scanning probe and detects current changes based on the distance between the nanopipette apex and the target sample in an electrolyte solution. In conventional SICM, the pipette sensor is excited by applying voltage as it raster scans near the surface. There have been attempts to improve upon raster scanning because it can induce collisions between the pipette sidewalls and target sample, especially for soft, dynamic materials (e.g., biological cells). Recently, Novak et al. demonstrated that hopping probe ion conductance microscopy (HPICM) with an adaptive scan method can improve the image quality obtained by SICM for such materials. However, HPICM is inherently slower than conventional raster scanning. In order to optimize both image quality and scanning speed, we report the development of an alternative configuration scheme for SICM signal amplification that is based on applying current to the nanopipette. This scheme overcomes traditional challenges associated with low bandwidth requirements of conventional SICM. Using our alternative scheme, we demonstrate successful imaging of L929 fibroblast cells and discuss the capabilities of this instrument configuration for future applications.
ISSN: 0034-6748
DOI: 10.1063/1.4907360
Rights: © 2015 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles
SCBE Journal Articles

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