Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107031
Title: From flab to fab : transforming surgical waste into an effective bioactive coating material
Authors: Luo, Baiwen
Yuan, Shaojun
Foo, Selin Ee Min
Wong, Marcus Thien Chong
Lim, Thiam Chye
Tan, Nguan Soon
Choong, Cleo Swee Neo
Keywords: DRNTU::Science::Medicine::Biomedical engineering
DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2014
Source: Luo, B., Yuan, S., Foo, S. E. M., Wong, M. T. C., Lim, T. C., Tan, N. S., et al. (2015). From flab to fab : transforming surgical waste into an effective bioactive coating material. Advanced healthcare materials, 4(4), 613-620.
Series/Report no.: Advanced healthcare materials
Abstract: Cellular events are regulated by the interaction between integrin receptors in the cell membrane and the extracellular matrix (ECM). Hence, ECM, as a material, can potentially play an instructive role in cell–material interactions. Currently, adipose tissue in the form of lipoaspirate is often discarded. Here, it is demonstrated how our chemical-free decellularization method could be used to obtain ECM from human lipoaspirate waste material. These investigations show that the main biological components are retained in the lipoaspirate-derived ECM (LpECM) material and that this LpECM material could subsequently be used as a coating material to confer bioactivity to an otherwise inert biodegradable material (i.e., polycaprolactone). Overall, lipoaspirate material, a complex blend of endogenous proteins, is effectively used a bioactive coating material. This work is an important stepping-stone towards the development of biohybrid scaffolds that contain cellular benefits without requiring the use of additional biologics based on commonly discarded lipoaspirate material.
URI: https://hdl.handle.net/10356/107031
http://hdl.handle.net/10220/25341
ISSN: 2192-2640
DOI: 10.1002/adhm.201400514
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles
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