Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107059
Title: Structure of a left-handed DNA G-quadruplex
Authors: Chung, Wan Jun
Heddi, Brahim
Schmitt, Emmanuelle
Lim, Kah Wai
Mechulam, Yves
Phan, Anh Tuân
Keywords: G-quadruplex
left-handed helix
nucleic acid
NMR
X-ray crystallography
Issue Date: 2015
Source: Chung, W. J., Heddi, B., Schmitt, E., Lim, K. W., Mechulam, Y., & Phan, A. T. (2015). Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2729-2733.
Series/Report no.: Proceedings of the National Academy of Sciences of the United States of America
Abstract: Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
URI: https://hdl.handle.net/10356/107059
http://hdl.handle.net/10220/25356
DOI: 10.1073/pnas.1418718112
Rights: © 2015 The Author(s) (Published by National Academy of Sciences). This is the author created version of a work that has been peer reviewed and accepted for publication by Proceedings of the National Academy of Sciences of the United States of America, The Author(s) (Published by National Academy of Sciences). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1073/pnas.1418718112].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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