Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107124
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dc.contributor.authorChi, Robin Yongguien
dc.contributor.authorXu, Jianfengen
dc.contributor.authorChen, Xingkuanen
dc.contributor.authorWang, Mingen
dc.contributor.authorZheng, Pengchengen
dc.contributor.authorSong, Bao-Anen
dc.date.accessioned2015-03-27T07:44:19Zen
dc.date.accessioned2019-12-06T22:25:15Z-
dc.date.available2015-03-27T07:44:19Zen
dc.date.available2019-12-06T22:25:15Z-
dc.date.copyright2015en
dc.date.issued2015en
dc.identifier.citationXu, J., Chen, X., Wang, M., Zheng, P., Song, B. A.,& Chi, Y. R. (2015). Aminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acids. Angewandte chemie International edition, 54(17), 5161-5165.en
dc.identifier.issn1433-7851en
dc.identifier.urihttps://hdl.handle.net/10356/107124-
dc.description.abstractA convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of azolium enolate intermediate, formaldehyde-derived iminium ion (as an electrophilic reactant), and methanol (as a nucleophilic reactant). This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.en
dc.language.isoenen
dc.relation.ispartofseriesAngewandte chemie International editionen
dc.rights© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.subjectDRNTU::Science::Chemistry::Physical chemistry::Catalysisen
dc.titleAminomethylation of enals through carbene and acid cooperative catalysis : concise access to β2-amino acidsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.identifier.doi10.1002/anie.201412132en
item.grantfulltextnone-
item.fulltextNo Fulltext-
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