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Title: Reductive cyclization and petasis-like reaction for the synthesis of functionalized γ-lactams
Authors: Wu, Peng
Petersen, Michael Åxman
Cohrt, A. Emil
Petersen, Rico
Clausen, Mads H.
Nielsen, Thomas E.
Keywords: DRNTU::Science::Chemistry::Organic chemistry
Issue Date: 2015
Source: Wu, P., Petersen, M. Å., Cohrt, A. E., Petersen, R., Clausen, M. H., & Nielsen, T. E. (2015). Reductive cyclization and petasis-like reaction for the synthesis of functionalized γ-lactams. European journal of organic chemistry, 2015(11), 2346-2350.
Series/Report no.: European journal of organic chemistry
Abstract: An efficient reductive cyclization strategy was employed for the synthesis of N-substituted β,γ-dihydroxy-γ-lactams. A subsequent Petasis-like reaction (PLR) through nucleophilic additions of boronic acids to intermediate N-acyliminium ions produced substituted γ-lactams. Overall, the application of this protocol provides β,γ-dihydroxy-γ-lactams and functionalized γ-lactams with potential interest for synthetic and bioorganic chemistry.
ISSN: 1434-193X
DOI: 10.1002/ejoc.201500143
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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