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Title: PANI : an interactive data-driven tool for target prioritization in signaling networks
Authors: Bhowmick, Sourav S.
Chua, Huey-Eng
Tucker-Kellogg, Lisa
Wang, Yingqi
Dewey Jr., C. Forbes
Yu, Hanry
Keywords: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
Issue Date: 2012
Source: Chua, H.-E., Bhowmick, S. S., Tucker-Kellogg, L., Wang, Y., Dewey, C. F., & Yu, H. (2012). PANI : an interactive data-driven tool for target prioritization in signaling networks. Proceedings of the 2nd ACM SIGHIT symposium on International health informatics-IHI '12, pp851-854.
Abstract: Biological network analysis often aims at the target identification problem, which is to predict which molecule to inhibit (or activate) for a disease treatment to achieve optimum efficacy and safety. A related goal, arising from the increasing availability of high-throughput screening (HTS), is to suggest many molecules as potential targets. The target prioritization problem is to predict a subset of molecules in a given disease-associated network which is likely to include successful drug targets. Sensitivity analysis prioritizes targets in a dynamic network model according to principled criteria, but fails to penalize off-target effects, and does not scale for large networks. In this demonstration, we present PANI(Putative TArget Nodes PrIoritization), a novel interactive system that addresses these limitations. It prunes and ranks the possible target nodes by exploiting concentration-time profiles and network structure (topological) information and visually display them in the context of the signaling network. Through the interactive user interface, we demonstrate various innovative features of PANI that enhance users' understanding of the prioritized nodes.
DOI: 10.1145/2110363.2110471
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCSE Conference Papers

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