Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107258
Title: A thioethylalkylamido (TEA) thioester surrogate in the synthesis of a cyclic peptide via a tandem acyl shift
Authors: Taichi, Misako
Hemu, Xinya
Qiu, Yibo
Tam, James P.
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2013
Source: Taichi, M., Hemu, X., Qiu, Y., & Tam, J. P. (2013). A thioethylalkylamido (TEA) thioester surrogate in the synthesis of a cyclic peptide via a tandem acyl shift. Organic letters, 15(11), 2620-2623.
Series/Report no.: Organic letters
Abstract: The cyclic cystine-knot peptide, kalata B1, was synthesized by employing a novel Fmoc-compatible thioethylalkylamido (TEA) thioester surrogate via an N–S acyl shift followed by a thiol-thioester exchange reaction. TEA thioester surrogate is cost-effective, conveniently prepared in one-step with starting materials, readily available from commercial sources, and highly efficient in preparing peptide thioesters.
URI: https://hdl.handle.net/10356/107258
http://hdl.handle.net/10220/18147
DOI: 10.1021/ol400801k
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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