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https://hdl.handle.net/10356/107258| Title: | A thioethylalkylamido (TEA) thioester surrogate in the synthesis of a cyclic peptide via a tandem acyl shift | Authors: | Taichi, Misako Hemu, Xinya Qiu, Yibo Tam, James P. |
Keywords: | DRNTU::Science::Biological sciences::Biochemistry | Issue Date: | 2013 | Source: | Taichi, M., Hemu, X., Qiu, Y., & Tam, J. P. (2013). A thioethylalkylamido (TEA) thioester surrogate in the synthesis of a cyclic peptide via a tandem acyl shift. Organic letters, 15(11), 2620-2623. | Series/Report no.: | Organic letters | Abstract: | The cyclic cystine-knot peptide, kalata B1, was synthesized by employing a novel Fmoc-compatible thioethylalkylamido (TEA) thioester surrogate via an N–S acyl shift followed by a thiol-thioester exchange reaction. TEA thioester surrogate is cost-effective, conveniently prepared in one-step with starting materials, readily available from commercial sources, and highly efficient in preparing peptide thioesters. | URI: | https://hdl.handle.net/10356/107258 http://hdl.handle.net/10220/18147 |
DOI: | 10.1021/ol400801k | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
| Appears in Collections: | SBS Journal Articles |
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