Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107348
Title: A digital micro magnetofluidic platform for lab-on-a-chip applications
Authors: Koh, Wei Hang
Lok, Khoi Seng
Nguyen, Nam-Trung
Keywords: DRNTU::Engineering::Mechanical engineering::Fluid mechanics
Issue Date: 2013
Source: Koh, W. H., Lok, K. S., & Nguyen, N.-T. (2013). A digital micro magnetofluidic platform for lab-on-a-chip applications. Journal of Fluids Engineering, 135(2), 021302.
Series/Report no.: Journal of Fluids Engineering
Abstract: This paper reports the design and investigation of a digital micro magnetofluidic platform for lab-on-a-chip applications. The platform allows a ferrofluid droplet to be driven along a preprogrammed path. The platform consists of a programmable x-y-positioning stage, a permanent magnet and a glass plate coated with a thin layer of Teflon. First, the actuation of a stand-alone water-based ferrofluid droplet was investigated. Circular, rectangular, triangular and number-eight-shape trajectories were tested and analyzed. The speed of the droplet is evaluated from the position data of the black ferrofluid using a customized MATLAB program. The results show that better positioning accuracy and steady movement can be achieved with smooth trajectories. Next, the ferrofluid droplet as the driving engine for a cargo of other diamagnetic liquid droplets is demonstrated. The characteristics of different cargo volumes are investigated. Due to the liquid/liquid cohesion, a large cargo of five times the volume of a 3-μL ferrofluid droplet can be transported. If the cargo is larger than the driving ferrofluid droplet, the liquid system forms a long trail that faithfully follows the preprogrammed path. Various mixing experiments were carried out. The effectiveness of mixing in this system is demonstrated with a titration test as well as a chemiluminescence assay. The platform shows a robust, simple and flexible concept for implementing a complex analysis protocol with multiple reaction steps.
URI: https://hdl.handle.net/10356/107348
http://hdl.handle.net/10220/16658
ISSN: 0098-2202
DOI: 10.1115/1.4023443
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MAE Journal Articles

SCOPUSTM   
Citations 20

24
Updated on Feb 7, 2023

Web of ScienceTM
Citations 10

25
Updated on Feb 2, 2023

Page view(s) 50

400
Updated on Feb 7, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.