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Title: One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging
Authors: Gu, Jun
Shum, Ping
Liu, Linbo
Cui, Dongyao
Liu, Xinyu
Zhang, Jing
Yu, Xiaojun
Sun, Ding
Luo, Yuemei
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2015
Source: Cui, D., Liu, X., Zhang, J., Yu, X., Sun, D., Luo, Y., et al. (2015). One-micron resolution optical coherence tomography (OCT) in vivo for cellular level imaging. Proceeding of SPIE, 9312.
Conference: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
Abstract: We developed a spectral domain OCT system combining two NIR, CW light sources of different spectral range. Its resolving power is validated by visualizing the cellular structures of zebra fish larvae in vivo. An NIR extended illumination from 755-1100 nm is achieved. The axial resolution is 1.27 μm in air, corresponding to 0.93μm in tissue (n=1.36), which is the highest axial resolution using NIR, CW laser sources up to date to the best of our knowledge. In vivo imaging is conducted to demonstrate the resolving power of proposed one-micron resolution OCT system. The top and bottom surfaces of individual disk-like red blood cell is reliably visualized, as well as flat, spindle shaped endothelial cells lining along the luminal surface of the blood vessel wall. This study provides a viable solution for cellular and subcellular level OCT imaging system which is also very competitive in cost.
DOI: 10.1117/12.2076438
Schools: School of Electrical and Electronic Engineering 
School of Chemical and Biomedical Engineering 
Rights: © 2015 SPIE. This paper was published in Proceeding of SPIE and is made available as an electronic reprint (preprint) with permission of SPIE. The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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