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Title: Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment
Authors: Azhari, Atiqah
Azizan, Farouq
Esposito, Gianluca
Keywords: Gut Microbiota
Social sciences::Psychology
Issue Date: 2019
Source: Azhari, A., Azizan, F., & Esposito, G. (2019). Beyond a gut feeling : how the immune system impacts the effect of gut microbiota in neurodevelopment. Behavioral and Brain Sciences, 42, e64-. doi:10.1017/S0140525X18002790
Series/Report no.: Behavioral and Brain Sciences
Abstract: Hooks et al. posit that gastrointestinal microbes alter the end state of development indirectly. Here, we present the immune system as the link that facilitates communication between the gut and the brain. Illustrating the case of autism spectrum disorder, we explicate the role of the immune system in responding to microbial dysbiosis by inducing an inflammatory state that affects neurodevelopment. We propose two models: directly, within the infant, and indirectly, via maternal and infant systems.
ISSN: 0140-525X
DOI: 10.1017/S0140525X18002790
Rights: © 2019 Cambridge University Press. All rights reserved. This paper was published in Behavioral and Brain Sciences and is made available with permission of Cambridge University Press.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SSS Journal Articles

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