Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/136484
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dc.contributor.authorZhang, Luen_US
dc.date.accessioned2019-12-19T06:02:16Z-
dc.date.available2019-12-19T06:02:16Z-
dc.date.issued2018-
dc.identifier.citationZhang, L. (2018). Design of plasmonic nanoparticles and their use for biotoxin immunosensing. Doctoral thesis, Nanyang Technological University, Singapore.en_US
dc.identifier.urihttps://hdl.handle.net/10356/136484-
dc.description.abstractGold nanoparticles (AuNPs) are widely used in the fields of biosensing, diagnostics, nanomedicine etc.1-5 Because of the incomparable affinity and specificity to target, antibody (Ab) as bioreceptor long has been used in conjunction with AuNPs. A good conjugation method should produce stable AuNP-Ab conjugates while maintaining the ability of the Ab to recognize and bind to its corresponding antigen. Thus, a robust conjugation method is of critical importance for improving the sensitivity of biosensors. To evaluate the coupling chemistry between Ab and AuNPs and quantify the Ab surface coverage on AuNPs, various quantification methods have been applied via direct or indirect approaches. In this review, we will focus on IgG-type antibodies conjugated to spherical AuNPs and present the strategies of conjugation, followed by quantification methods of Ab surface coverage, and finally selected applications in optical biosensing.en_US
dc.language.isoenen_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.subjectEngineering::Materialsen_US
dc.titleDesign of plasmonic nanoparticles and their use for biotoxin immunosensingen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorBo Liedbergen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.degreeDoctor of Philosophyen_US
dc.contributor.organizationCentre for Biomimetic Sensor Scienceen_US
dc.contributor.supervisor2Souhir Boujdayen_US
dc.contributor.supervisoremailbliedberg@ntu.edu.sgen_US
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