Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/136602
Title: Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
Authors: Fun, Xiu Hui
Thibault, Guillaume
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Fun, X. H. & Thibault, G. (2020). Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865(1), 1-9. doi:10.1016/j.bbalip.2019.04.009
Journal: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Abstract: The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restorecellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programmeregulates the expression of hundreds of genes in response to signalling from ATF6, IRE1, and PERK. These threehighly conserved stress sensors are activated by the accumulation of unfolded proteins within the ER.Alternatively, IRE1 and PERK sense generalised lipid bilayer stress (LBS) at the ER while ATF6 is activated by anincrease of specific sphingolipids. As a result, the UPR supports cellular robustness as a broad-spectrum com-pensatory pathway that is achieved by deploying a tailored transcriptional programme adapted to the source ofER stress. This review summarises the current understanding of the three ER stress transducers in sensingproteotoxic stress and LBS. The plasticity of the UPR programme in the context of different sources of ER stresswill also be discussed.
URI: https://hdl.handle.net/10356/136602
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2019.04.009
212240
212240
Schools: School of Biological Sciences 
Rights: © 2019 Elsevier. All rights reserved. This paper was published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and is made available with permission of Elsevier.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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