Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/136602
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dc.contributor.authorFun, Xiu Huien_US
dc.contributor.authorThibault, Guillaumeen_US
dc.date.accessioned2020-01-06T08:37:59Z-
dc.date.available2020-01-06T08:37:59Z-
dc.date.copyright2019en
dc.date.issued2020-
dc.identifier.citationFun, X. H. & Thibault, G. (2020). Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865(1), 1-9. doi:10.1016/j.bbalip.2019.04.009en_US
dc.identifier.issn1388-1981en_US
dc.identifier.urihttps://hdl.handle.net/10356/136602-
dc.description.abstractThe unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress and is designed to restorecellular homeostasis through multiple intracellular signalling pathways. In mammals, the UPR programmeregulates the expression of hundreds of genes in response to signalling from ATF6, IRE1, and PERK. These threehighly conserved stress sensors are activated by the accumulation of unfolded proteins within the ER.Alternatively, IRE1 and PERK sense generalised lipid bilayer stress (LBS) at the ER while ATF6 is activated by anincrease of specific sphingolipids. As a result, the UPR supports cellular robustness as a broad-spectrum com-pensatory pathway that is achieved by deploying a tailored transcriptional programme adapted to the source ofER stress. This review summarises the current understanding of the three ER stress transducers in sensingproteotoxic stress and LBS. The plasticity of the UPR programme in the context of different sources of ER stresswill also be discussed.en_US
dc.language.isoenen_US
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipidsen_US
dc.rights© 2019 Elsevier. All rights reserved. This paper was published in Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids and is made available with permission of Elsevier.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleLipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1016/j.bbalip.2019.04.009-
dc.identifier.doi212240-
dc.identifier.doi212240-
dc.description.versionAccepted versionen_US
dc.identifier.issue1en_US
dc.identifier.volume1865en_US
dc.identifier.spage1en_US
dc.identifier.epage9en_US
dc.subject.keywordsEndoplasmic Reticulum Stressen_US
dc.subject.keywordsUnfolded Protein Responseen_US
dc.identifier.rims212240en
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