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Title: Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries
Authors: Ong, William
Pinese, Coline
Chew, Sing Yian
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Ong, W., Pinese, C., & Chew, S. Y. (2019). Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries. Advanced Drug Delivery Reviews, 149-15019-48. doi:10.1016/j.addr.2019.03.004
Journal: Advanced Drug Delivery Reviews
Abstract: Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field of neural tissue engineering has evolved to find therapeutic interventions and has seen promising outcomes. However, robust nerve and myelin regeneration remain elusive. One possible reason may be the fact that tissue regeneration often follows a complex sequence of events in a temporally-controlled manner. Although several other fields of tissue engineering have begun to recognise the importance of delivering two or more biomolecules sequentially for more complete tissue regeneration, such serial delivery of biomolecules in neural tissue engineering remains limited. This review aims to highlight the need for sequential delivery to enhance nerve regeneration and remyelination after traumatic injuries in the central nervous system, using spinal cord injuries as an example. In addition, possible methods to attain temporally-controlled drug/gene delivery are also discussed for effective neural tissue regeneration.
ISSN: 0169-409X
DOI: 10.1016/j.addr.2019.03.004
Schools: School of Chemical and Biomedical Engineering 
Interdisciplinary Graduate School (IGS) 
Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2019 Elsevier. All rights reserved. This paper was published in Advanced Drug Delivery Reviews and is made available with permission of Elsevier.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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