Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/136719
Title: A renal-clearable duplex optical reporter for real-time imaging of contrast-induced acute kidney injury
Authors: Huang, Jiaguo
Lyu, Yan
Li, Jingchao
Cheng, Penghui
Jiang, Yuyan
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Huang, J., Lyu, Y., Li, J., Cheng, P., Jiang, Y., & Pu, K. (2019). A renal-clearable duplex optical reporter for real-time imaging of contrast-induced acute kidney injury. Angewandte Chemie International Edition, 58(49), 17796-17804. doi:10.1002/anie.201910137
Journal: Angewandte Chemie International Edition
Abstract: Despite its high morbidity and mortality, contrast‐induced acute kidney injury (CIAKI) remains a diagnostic dilemma because it relies on in vitro detection of insensitive late‐stage blood and urinary biomarkers. We report the synthesis of an activatable duplex reporter (ADR) for real‐time in vivo imaging of CIAKI. ADR is equipped with chemiluminescence and near‐infrared fluorescence (NIRF) signaling channels that can be activated by oxidative stress (superoxide anion, O2.−) and lysosomal damage (N‐acetyl‐β‐d‐glucosaminidase, NAG), respectively. By virtue of its high renal clearance efficiency (80 % injected doses after 24 h injection), ADR detects sequential upregulation of O2.− and NAG in the kidneys of living mice prior to a significant decrease in glomerular filtration rate (GFR) and tissue damage in the course of CIAKI. ADR outperforms the typical clinical assays and detects CIAKI at least 8 h (NIRF) and up to 16 h (chemiluminescence) earlier.
URI: https://hdl.handle.net/10356/136719
ISSN: 1433-7851
DOI: 10.1002/anie.201910137
Rights: This is the peer reviewed version of the following article: Huang, J., Lyu, Y., Li, J., Cheng, P., Jiang, Y., & Pu, K. (2019). A renal-clearable duplex optical reporter for real-time imaging of contrast-induced acute kidney injury. Angewandte Chemie International Edition, 58(49), 17796-17804. doi:10.1002/anie.201910137, which has been published in final form at https://doi.org/10.1002/anie.201910137. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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