Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/136963
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dc.contributor.authorRidhwan Yusoffen_US
dc.contributor.authorKathawala, Mustafa Hussainen_US
dc.contributor.authorNguyen, Luong Thi Hienen_US
dc.contributor.authorSetyawati, Magdiel Inggriden_US
dc.contributor.authorChiew, Paulen_US
dc.contributor.authorWu, Yuanshengen_US
dc.contributor.authorCh'ng, Ai Leeen_US
dc.contributor.authorWang, Zheng Mingen_US
dc.contributor.authorNg, Kee Woeien_US
dc.date.accessioned2020-02-07T05:10:57Z-
dc.date.available2020-02-07T05:10:57Z-
dc.date.issued2018-
dc.identifier.citationRidhwan Yusoff., Kathawala, M. H., Nguyen, L. T. H., Setyawati, M. I., Chiew, P., Wu, Y. et al. (2018). Biomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticles. Nanoimpact, 12, 51-57. doi:10.1016/j.impact.2018.10.001en_US
dc.identifier.issn2452-0748en_US
dc.identifier.urihttps://hdl.handle.net/10356/136963-
dc.description.abstractTitanium dioxide (TiO2) nanoparticles (NPs) are used abundantly as food additives (E171). For the purpose of risk assessment, it is imperative to understand the behavior of these nanoparticles in a food relevant environment, and their consequent toxicology impacts. However, most of such studies use model TiO2 NPs (P25) as substitutes for E171. To understand the suitability of this approach, we investigated the functional behavior of E171 and P25 in solutions of bovine serum albumin (BSA) and sucrose as model food ingredients. Our data showed that E171 were better dispersed in BSA than P25. In sucrose, E171 displayed a reduction in agglomerated size while P25 agglomerated extensively. Adsorption studies showed that P25 attracted more pronounced corona formation per unit mass of material compared to E171. In vitro sedimentation, diffusion and dosimetry (ISDD) results demonstrated that the time-weighted dosage of E171 was more than two-folds higher than P25, implying that any test performed using P25 to model E171 would underestimate actual dosage and potential toxicity. Taken collectively, this study demonstrated the specificity of TiO2 nanoparticle interaction with food ingredients, and the importance of using food-grade E171 TiO2 for food-relevant toxicological assessments.en_US
dc.language.isoenen_US
dc.relation.ispartofNanoImpacten_US
dc.rights© 2018 Elsevier B.V. All rights reserved. This paper was published in Nanoimpact and is made available with permission of Elsevier B.V.en_US
dc.subjectEngineering::Materialsen_US
dc.titleBiomolecular interaction and kinematics differences between P25 and E171 TiO2 nanoparticlesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen_US
dc.identifier.doi10.1016/j.impact.2018.10.001-
dc.description.versionAccepted versionen_US
dc.identifier.scopus2-s2.0-85055441764-
dc.identifier.volume12en_US
dc.identifier.spage51en_US
dc.identifier.epage57en_US
dc.subject.keywordsNanoparticlesen_US
dc.subject.keywordsTitanium Dioxideen_US
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