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Title: Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging
Authors: Raveendran, Sreejith
Lim, Hoong-Ta
Maekawa, Toru
Vadakke Matham, Murukeshan
Sakthi Kumar, D.
Keywords: Engineering::Mechanical engineering
Issue Date: 2018
Source: Raveendran, S., Lim, H.-T., Maekawa, T., Vadakke Matham, M., & Sakthi Kumar, D. (2018). Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. Nanoscale, 10(29), 13959-13968. doi:10.1039/c8nr02866d
Journal: Nanoscale
Abstract: Bioinert gold nanoparticles of various shapes and functionalities are widely accepted as contrast agents (CAs) for several modalities of imaging, viz., electron microscopy, computerized tomography (CT), X-ray and photoacoustic (PA) imaging. However, testing of novel compact-imaging probes for ocular diagnostic imaging is always challenging. Here, ultra-fast microwave oven synthesized gold nanocages (AuNcgs) were successfully demonstrated for high-contrast PA ocular imaging for the first time. Methods are described for the synthesis, characterization and application of quickly synthesized AuNcgs in diagnostic ocular imaging. PA and ultrasound (US) images were acquired using a commercial US imaging scanner integrated with a tunable nanosecond pulsed laser. This integrated hybrid-modality system is a combined PA and US platform for imaging which enabled acquiring of complementary structural and optical absorption-based information simultaneously. Initial experiments were conducted using tubings filled with solutions of different concentrations of quickly synthesized AuNcgs. Biological PA and US imagings were demonstrated using enucleated porcine eye samples. Based on the acquired results, it is envisaged that AuNcgs can be employed as a high strength PA CA to potentially diagnose ocular disease like uveal melanoma in the near future.
ISSN: 2040-3364
DOI: 10.1039/C8NR02866D
Schools: School of Mechanical and Aerospace Engineering 
Organisations: Centre for Optical and Laser Engineering
Rights: © 2018 The Royal Society of Chemistry. All rights reserved. This paper was published in Nanoscale and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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