Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRaveendran, Sreejithen_US
dc.contributor.authorLim, Hoong-Taen_US
dc.contributor.authorMaekawa, Toruen_US
dc.contributor.authorVadakke Matham, Murukeshanen_US
dc.contributor.authorSakthi Kumar, D.en_US
dc.identifier.citationRaveendran, S., Lim, H.-T., Maekawa, T., Vadakke Matham, M., & Sakthi Kumar, D. (2018). Gold nanocages entering into the realm of high-contrast photoacoustic ocular imaging. Nanoscale, 10(29), 13959-13968. doi:10.1039/c8nr02866den_US
dc.description.abstractBioinert gold nanoparticles of various shapes and functionalities are widely accepted as contrast agents (CAs) for several modalities of imaging, viz., electron microscopy, computerized tomography (CT), X-ray and photoacoustic (PA) imaging. However, testing of novel compact-imaging probes for ocular diagnostic imaging is always challenging. Here, ultra-fast microwave oven synthesized gold nanocages (AuNcgs) were successfully demonstrated for high-contrast PA ocular imaging for the first time. Methods are described for the synthesis, characterization and application of quickly synthesized AuNcgs in diagnostic ocular imaging. PA and ultrasound (US) images were acquired using a commercial US imaging scanner integrated with a tunable nanosecond pulsed laser. This integrated hybrid-modality system is a combined PA and US platform for imaging which enabled acquiring of complementary structural and optical absorption-based information simultaneously. Initial experiments were conducted using tubings filled with solutions of different concentrations of quickly synthesized AuNcgs. Biological PA and US imagings were demonstrated using enucleated porcine eye samples. Based on the acquired results, it is envisaged that AuNcgs can be employed as a high strength PA CA to potentially diagnose ocular disease like uveal melanoma in the near future.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.rights© 2018 The Royal Society of Chemistry. All rights reserved. This paper was published in Nanoscale and is made available with permission of The Royal Society of Chemistry.en_US
dc.subjectEngineering::Mechanical engineeringen_US
dc.titleGold nanocages entering into the realm of high-contrast photoacoustic ocular imagingen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.organizationCentre for Optical and Laser Engineeringen_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsGold Compoundsen_US
dc.subject.keywordsPhotoacoustic Techniquesen_US
item.fulltextWith Fulltext-
Appears in Collections:MAE Journal Articles
Files in This Item:
File Description SizeFormat 
Gold Nanocages Entering into the 1 Realm of High-contrast.pdf995.28 kBAdobe PDFThumbnail

Citations 20

Updated on Mar 20, 2023

Web of ScienceTM
Citations 20

Updated on Mar 18, 2023

Page view(s)

Updated on Mar 20, 2023

Download(s) 50

Updated on Mar 20, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.