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Title: Organic semiconducting polymer nanoparticles for photoacoustic labeling and tracking of stem cells in the second near-infrared window
Authors: Yin, Chao
Wen, Guohua
Liu, Chao
Yang, Boguang
Lin, Sien
Huang, Jiawei
Zhao, Pengchao
Wong, Dexter Siu Hong
Zhang, Kunyu
Chen, Xiaoyu
Li, Gang
Jiang, Xiaohua
Huang, Jianping
Pu, Kanyi
Wang, Lidai
Bian, Liming
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Yin, C., Wen, G., Liu, C., Yang, B., Lin, S., Huang, J., . . . Bian, L. (2018). Organic semiconducting polymer nanoparticles for photoacoustic labeling and tracking of stem cells in the second near-infrared window. ACS Nano, 12(12), 12201-12211. doi:10.1021/acsnano.8b05906
Journal: ACS nano
Abstract: Photoacoustic (PA) imaging and tracking of stem cells plays an important role in the real-time assessment of cell-based therapies. Nevertheless, the limitations of conventional inorganic PA contrast agents and the narrow range of the excitation wavelength in the first near-infrared (NIR-I) window hamper the applications of PA imaging in living subjects. Herein, we report the design and synthesis of a second near-infrared (NIR-II) absorptive organic semiconducting polymer (OSP)-based nanoprobe (OSPN+) for PA imaging and tracking of stem cells. Comparison studies in biological tissue show that NIR-II light excited PA imaging of the OSPN+ has significantly higher signal-to-noise ratio than NIR-I light excited PA imaging, thereby demonstrating the superiority of the OSPN+ for deep tissue imaging. With good biocompatibility, appropriate size, and optimized surface property, the OSPN+ shows enhanced cellular uptake for highly efficient PA labeling of stem cells. In vivo investigations reveal significant NIR-II PA contrast enhancement of the transplanted OSPN+-labeled human mesenchymal stem cells by 40.6- and 21.7-fold in subcutaneous and brain imaging, respectively, compared with unlabeled cases. Our work demonstrates a class of OSP-based nanomaterials for NIR-II PA stem cell imaging to facilitate a better understanding and evaluation of stem cell-based therapies.
ISSN: 1936-0851
DOI: 10.1021/acsnano.8b05906
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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