Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137158
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dc.contributor.authorCui, Dongen_US
dc.contributor.authorXie, Chenen_US
dc.contributor.authorLi, Jingchaoen_US
dc.contributor.authorLyu, Yanen_US
dc.contributor.authorPu, Kanyien_US
dc.date.accessioned2020-03-04T04:14:56Z-
dc.date.available2020-03-04T04:14:56Z-
dc.date.issued2018-
dc.identifier.citationCui, D., Xie, C., Li, J., Lyu, Y., & Pu, K. (2018). Semiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imaging. Advanced healthcare materials, 7(18), 1800329-. doi:10.1002/adhm.201800329en_US
dc.identifier.issn2192-2640en_US
dc.identifier.urihttps://hdl.handle.net/10356/137158-
dc.description.abstractThe fact that cancer metastasis is the main cause of death for most cancer patients necessitates the development of imaging tools for sensitive detection of metastases. Although optical imaging has high temporospatial resolution, tissue autofluorescence compromises the sensitivity for in vivo imaging of cancer metastasis. Herein, the synthesis of a series of photosensitizer-incorporated poly(p-phenylenevinylene)-based semiconducting copolymers and their utility as near-infrared (NIR) afterglow imaging nanoagents that emit light after cessation of light irradiation are reported. As compared with nondoped nanoparticles, the nanoparticles derived from the photosensitizer-incorporated copolymers have red-shifted NIR luminescence and amplified afterglow signals, allowing the detection of tiny peritoneal metastatic tumors almost invisible to naked eye. Moreover, the intrinsic oxygen-sensitive nature of afterglow makes those nanoagents potentially useful for in vivo imaging of oxygen levels. Thus, this study introduces a generation of light-excitation-free background-minimized optical imaging agents for the sensitive detection of diseased tissues in vivo.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofAdvanced healthcare materialsen_US
dc.rightsThis is the peer reviewed version of the following article: Cui, D., Xie, C., Li, J., Lyu, Y., & Pu, K. (2018). Semiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imaging. Advanced healthcare materials, 7(18), 1800329-., which has been published in final form at https://doi.org/10.1002/adhm.201800329. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleSemiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imagingen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/adhm.201800329-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30080302-
dc.identifier.scopus2-s2.0-85052380742-
dc.identifier.issue18en_US
dc.identifier.volume7en_US
dc.subject.keywordsAfterglow Imagingen_US
dc.subject.keywordsNear‐infrared Fluorescenceen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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