Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137158
Title: Semiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imaging
Authors: Cui, Dong
Xie, Chen
Li, Jingchao
Lyu, Yan
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Cui, D., Xie, C., Li, J., Lyu, Y., & Pu, K. (2018). Semiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imaging. Advanced healthcare materials, 7(18), 1800329-. doi:10.1002/adhm.201800329
Journal: Advanced healthcare materials
Abstract: The fact that cancer metastasis is the main cause of death for most cancer patients necessitates the development of imaging tools for sensitive detection of metastases. Although optical imaging has high temporospatial resolution, tissue autofluorescence compromises the sensitivity for in vivo imaging of cancer metastasis. Herein, the synthesis of a series of photosensitizer-incorporated poly(p-phenylenevinylene)-based semiconducting copolymers and their utility as near-infrared (NIR) afterglow imaging nanoagents that emit light after cessation of light irradiation are reported. As compared with nondoped nanoparticles, the nanoparticles derived from the photosensitizer-incorporated copolymers have red-shifted NIR luminescence and amplified afterglow signals, allowing the detection of tiny peritoneal metastatic tumors almost invisible to naked eye. Moreover, the intrinsic oxygen-sensitive nature of afterglow makes those nanoagents potentially useful for in vivo imaging of oxygen levels. Thus, this study introduces a generation of light-excitation-free background-minimized optical imaging agents for the sensitive detection of diseased tissues in vivo.
URI: https://hdl.handle.net/10356/137158
ISSN: 2192-2640
DOI: 10.1002/adhm.201800329
Rights: This is the peer reviewed version of the following article: Cui, D., Xie, C., Li, J., Lyu, Y., & Pu, K. (2018). Semiconducting photosensitizer-incorporated copolymers as near-infrared afterglow nanoagents for tumor imaging. Advanced healthcare materials, 7(18), 1800329-., which has been published in final form at https://doi.org/10.1002/adhm.201800329. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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