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Title: A dual-modal molecular probe for near-infrared fluorescence and photoacoustic imaging of peroxynitrite
Authors: Zhang, Jianjian
Zhen, Xu
Zeng, Jianfeng
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Zhang, J., Zhen, X., Zeng, J., & Pu, K. (2018). A dual-modal molecular probe for near-infrared fluorescence and photoacoustic imaging of peroxynitrite. Analytical chemistry, 90(15), 9301-9307. doi:10.1021/acs.analchem.8b01879
Journal: Analytical chemistry
Abstract: Peroxynitrite (ONOO-), a reactive and short-lived biological oxidant, is closely related with many pathological conditions such as cancer. However, real-time in vivo imaging of ONOO- in tumors remains to be challenging. Herein, we develop a near-infrared fluorescence (NIRF) and photoacoustic dual-modal molecular probe (CySO3CF3) composed of a water-soluble hemicyanine dye caged with a trifluoromethyl ketone moiety for in vivo imaging of ONOO-. The trifluoromethyl ketone moiety can undergo a series of ONOO--induced cascade oxidation-elimination reactions, leading to sensitive and specific fluorescence and photoacoustic turn-on responses toward ONOO-; whereas, a zwitterionic structure of the hemicyanine component ensures good water-solubility. Thus, CySO3CF3 not only specifically detects ONOO- in solution and cells with the limit of detection down to 53 nM but also allows for NIRF and photoacoustic dual-modal imaging of ONOO- in the tumors of living mice.
ISSN: 0003-2700
DOI: 10.1021/acs.analchem.8b01879
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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