Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137249
Title: Versatile types of DNA-based nanobiosensors for specific detection of cancer biomarker FEN1 in living cells and cell-free systems
Authors: Zhang, Hao
Ba, Sai
Mahajan, Divyanshu
Lee, Jasmine Yiqin
Ye, Ruijuan
Shao, Fangwei
Lu, Lei
Li, Tianhu
Keywords: Science::Biological sciences
Issue Date: 2018
Source: Zhang, H., Ba, S., Mahajan, D., Lee, J. Y., Ye, R., Shao, F., . . . Li, T. (2018). Versatile types of DNA-based nanobiosensors for specific detection of cancer biomarker FEN1 in living cells and cell-free systems. Nano Letters, 18, 7383-7388. doi:10.1021/acs.nanolett.8b03724
Journal: Nano Letters
Abstract: Flap structure-specific endonuclease 1 (FEN1) is overexpressed in various types of human cancer cells and has been recognized as a promising biomarker for cancer diagnosis in the recent years. In order to specifically detect the abundance and activity of this cancer-overexpressed enzyme, different types of DNA-based nanodevices were created during our investigations. It is shown in our studies that these newly designed biosensors are highly sensitive and specific for FEN1 in living cells as well as in cell-free systems. It is expected that these nanoprobes could be useful for monitoring FEN1 activity in human cancer cells, and also for cell-based screening of FEN1 inhibitors as new anticancer drugs.
URI: https://hdl.handle.net/10356/137249
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.8b03724
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.8b03724
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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