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dc.contributor.authorYu, Xiaojunen_US
dc.contributor.authorTang, Hongyingen_US
dc.contributor.authorHu, Chien_US
dc.contributor.authorDing, Qianshanen_US
dc.contributor.authorWang, Luluen_US
dc.contributor.authorWang, Xianghongen_US
dc.contributor.authorFan, Zemingen_US
dc.contributor.authorLiu, Linboen_US
dc.identifier.citationYu, X., Tang, H., Hu, C., Ding, Q., Wang, L., Wang, X., . . . Liu, L. (2018). Multiscale skin imaging in vivo using optical coherence tomography. Laser Physics Letters, 15(7), 075601-. doi:10.1088/1612-202X/aabb2fen_US
dc.description.abstractOptical coherence tomography (OCT) is a noninvasive high-resolution diagnostic imaging modality that plays an increasingly important role in dermatology. Diagnosis of skin diseases using OCT requires both cellular-level high resolution and large area skin coverage. In practice, however, there exists a trade-off between the achievable spatial resolutions and the transverse scanning range. In this study, we report a Micro-OCT (μOCT) system that is capable of providing three-dimensional images of the skin at multiple spatial scales with both cellular-level resolution (1-2 μm) mode and large area (∼ mm2) scanning mode. Specifically, in the cellular-level scanning mode, we achieve a transverse resolution of ∼1.5 μm and an axial resolution of 1.7 μm (n = 1.38) which enables the visualization of cellular-level skin microstructures. While in the large-area scanning mode, the system is capable of covering an en face imaging area reaching up to with a lateral resolution of ∼5.5 μm at a scanning speed of 60 K Alines/s. We experimentally verify the imaging capabilities of such a multiscale μOCT system including in vivo visualization of epidermal cells in the cellular-level scanning mode as well as the internal fingerprints and sweat gland ducts in the large area scanning mode. Micro-anatomical imaging at multiple spatial scales could provide comprehensive information of the skin that is valuable to disease diagnosis.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.relation.ispartofLaser Physics Lettersen_US
dc.rights© 2018 Astro Ltd. All rights reserved. This paper was published by IOP Publishing in Laser Physics Letters and is made available with permission of Astro Ltd. A Creative Commons Licence, or any other form of open access licence, may not be attached to articles published under the subscription model. For example, authors may not post the Accepted Manuscript in non-commercial repositories or noncommercial Scientific Social Networks which automatically apply an open access licence to the article which grants reuse rights under the terms of the repository or Scientific Social Network.en_US
dc.subjectEngineering::Electrical and electronic engineeringen_US
dc.titleMultiscale skin imaging in vivo using optical coherence tomographyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsOptical Coherence Tomographyen_US
dc.subject.keywordsImaging Systemsen_US
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