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Title: Multiscale skin imaging in vivo using optical coherence tomography
Authors: Yu, Xiaojun
Tang, Hongying
Hu, Chi
Ding, Qianshan
Wang, Lulu
Wang, Xianghong
Fan, Zeming
Liu, Linbo
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2018
Source: Yu, X., Tang, H., Hu, C., Ding, Q., Wang, L., Wang, X., . . . Liu, L. (2018). Multiscale skin imaging in vivo using optical coherence tomography. Laser Physics Letters, 15(7), 075601-. doi:10.1088/1612-202X/aabb2f
Journal: Laser Physics Letters
Abstract: Optical coherence tomography (OCT) is a noninvasive high-resolution diagnostic imaging modality that plays an increasingly important role in dermatology. Diagnosis of skin diseases using OCT requires both cellular-level high resolution and large area skin coverage. In practice, however, there exists a trade-off between the achievable spatial resolutions and the transverse scanning range. In this study, we report a Micro-OCT (μOCT) system that is capable of providing three-dimensional images of the skin at multiple spatial scales with both cellular-level resolution (1-2 μm) mode and large area (∼ mm2) scanning mode. Specifically, in the cellular-level scanning mode, we achieve a transverse resolution of ∼1.5 μm and an axial resolution of 1.7 μm (n = 1.38) which enables the visualization of cellular-level skin microstructures. While in the large-area scanning mode, the system is capable of covering an en face imaging area reaching up to with a lateral resolution of ∼5.5 μm at a scanning speed of 60 K Alines/s. We experimentally verify the imaging capabilities of such a multiscale μOCT system including in vivo visualization of epidermal cells in the cellular-level scanning mode as well as the internal fingerprints and sweat gland ducts in the large area scanning mode. Micro-anatomical imaging at multiple spatial scales could provide comprehensive information of the skin that is valuable to disease diagnosis.
ISSN: 1621-2011
DOI: 10.1088/1612-202X/aabb2f
Rights: © 2018 Astro Ltd. All rights reserved. This paper was published by IOP Publishing in Laser Physics Letters and is made available with permission of Astro Ltd. A Creative Commons Licence, or any other form of open access licence, may not be attached to articles published under the subscription model. For example, authors may not post the Accepted Manuscript in non-commercial repositories or noncommercial Scientific Social Networks which automatically apply an open access licence to the article which grants reuse rights under the terms of the repository or Scientific Social Network.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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