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Title: Inhibiting S100B(ββ) for activating wild-type p53 : design of stapled peptides
Authors: Kannan, Srinivasaraghavan
Aronica, Pietro G. A.
Tan, Yaw Sing
Verma, Chandra Shekhar
Keywords: Science::Biological sciences
Issue Date: 2019
Source: Kannan, S., Aronica, P. G. A., Tan, Y. S., & Verma, C. S. (2019). Inhibiting S100B(ββ) for activating wild-type p53 : design of stapled peptides. ACS Omega, 4(3), 5335-5344. doi:10.1021/acsomega.9b00097
Journal: ACS Omega 
Abstract: S100B(ββ) is a member of the S100B protein family and is distributed in a cell-specific manner. Its levels are elevated in several cancers such as malignant melanoma and correlate directly with poor prognosis in patients. S100B(ββ) directly interacts with the tumor suppressor p53, inhibiting tetramerization and protein kinase C-dependent phosphorylation, consequently decreasing p53 DNA binding and transcriptional activity, and preventing apoptosis. Thus, S100B(ββ) is being pursued as a target for therapeutic inhibition. However, development of small molecule inhibitors targeting p53-interactions has met with limited success. In this work, we present a set of designed stapled peptide inhibitors of S100B(ββ), guided by the structure of the C-terminal domain of p53 complexed with S100B(ββ). We further modified a tightly binding stapled peptide with imaging agents and propose these as potential diagnostic agents to detect S100B(ββ) as a biomarker.
ISSN: 2470-1343
DOI: 10.1021/acsomega.9b00097
Schools: School of Biological Sciences 
Rights: © 2019 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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