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Title: 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves
Authors: Tao, Xiang
Nguyen, Tan Dai
Jin, Hao
Tao, Ran
Lou, Jingting
Yang, Xin
Torun, Hamdi
Zhou, Jian
Huang, Shuyi
Shi, Lin
Gibson, Des
Cooke, Michael
Du, Hejun
Dong, Shurong
Luo, Jikui
Fu, YongQing
Keywords: Engineering::Mechanical engineering
Issue Date: 2019
Source: Tao, X., Nguyen, T. D., Jin, H., Tao, R., Luo, J., Yang, X., ... Fu, Y. (2019). 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators B: Chemical, 299126991-. doi:10.1016/j.snb.2019.126991
Project: 2018-T1-001-081
Journal: Sensors and Actuators B: Chemical
Abstract: Manipulating biological cells or microparticles in three dimensions (3D) is invaluable for many biomedical applications, and recently effective and rapid manipulations of microparticles in 2D and 3D within microchannels or chambers using surface acoustic waves (SAWs) with bulk piezoelectric materials have been reported. However, these are generally expensive, or brittle and cannot be easily integrated into a single lab-on-chip. In this paper, we realized microparticle/cell patterning and 3D manipulation of yeast cells inside a chamber with a height of 1 mm using thin film ZnO/Si SAW devices. Effects of SAW frequency, channel width and thickness on alignment of microparticles were firstly investigated, and positions of the microparticles in the direction of SAW propagation can be controlled precisely by changing the phase angle of the acoustic waves from the ZnO/Si SAW device. A numerical model has been developed to investigate the SAW acoustic field and the resulted 3D motions of microparticles under the acoustic radiation forces within the microchamber. Finally, we realized and observed the 3D patterning of yeast cells within the microchannel. Our work shows a great potential for acoustofluidic, neural network research and biomedical applications using the ZnO/Si SAW devices.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2019.126991
Rights: © 2019 Elsevier. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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