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dc.contributor.authorOng, Wee Kongen_US
dc.identifier.citationOng, W. K. (2019). Reactive oxygen species-mediated cancer therapy with silica-based nanoparticles. Doctoral thesis, Nanyang Technological University, Singapore.en_US
dc.description.abstractReactive oxygen species (ROS) is important for the well-being of cells since they served as messengers. However, too much ROS will kill them because of their high reactivity with DNA and surrounding organelles. Nanoparticles made from silica and ROS-producing agents have been successfully synthesized. They can manipulate the ROS within cancer cells by raising it to apoptotic or necrosis levels. The first project talks about the use of a nanoreactor that produces ·OH radicals independently. A photosensitizer was loaded into it as well to generate even more radicals for enhanced therapy. This was subsequently subjected to both in-vitro and in vivo testing. The second project explores the use of a new ligand to fabricate an organically modified silica nanocomposite capable of not only generating the ROS H2O2, but reducing the antioxidant capabilities of cancer cells to enhance the effectiveness of the produced ROS. The third project combined the use of the nanoreactor in the first project with a silane conjugated glucose oxidase for increased ·OH radicals production. In summary, this thesis showed that ROS can be effectively exploited to treat cancer.en_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.titleReactive oxygen species-mediated cancer therapy with silica-based nanoparticlesen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorZhao Yanlien_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.degreeDoctor of Philosophyen_US
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