Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137613
Title: Degradability and clearance of inorganic nanoparticles for biomedical applications
Authors: Yang, Guangbao
Phua, Fiona Soo Zeng
Bindra, Anivind Kaur
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2019
Source: Yang, G., Phua, F. S. Z., Bindra, A. K., & Zhao, Y. (2019). Degradability and clearance of inorganic nanoparticles for biomedical applications. Advanced Materials, 31, 1805730. doi:10.1002/adma.201805730
Journal: Advanced Materials
Abstract: Inorganic nanoparticles with tunable and diverse properties hold tremendous potential in the field of nanomedicine, while having non-negligible toxicity concerns in healthy tissues/organs that have resulted in their restricted clinical translation to date. In the past decade, the emergence of biodegradable or clearable inorganic nanoparticles has made it possible to completely solve this long-standing conundrum. A comprehensive understanding of the design of these inorganic nanoparticles with their metabolic performance in the body is of crucial importance to advance clinical trials and expand their biological applications in disease diagnosis. Here, a diverse variety of biodegradable or clearable inorganic nanoparticles regarding considerations of the size, morphology, surface chemistry, and doping strategy are highlighted. Their pharmacokinetics, pathways of metabolism in the body, and time required for excretion are discussed. Some inorganic materials intrinsically responsive to various conditions in the tumor microenvironment are also introduced. Finally, an overview of the encountered challenges is provided along with an outlook for applying these inorganic nanoparticles toward future clinical translations.
URI: https://hdl.handle.net/10356/137613
ISSN: 0935-9648
DOI: 10.1002/adma.201805730
Rights: This is the peer reviewed version of the following article: Yang, G., Phua, F. S. Z., Bindra, A. K., & Zhao, Y. (2019). Degradability and clearance of inorganic nanoparticles for biomedical applications. Advanced Materials, 31, 1805730. doi:10.1002/adma.201805730, which has been published in final form at 10.1002/adma.201805730. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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