Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137650
Title: NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy
Authors: Chen, Hongzhong
Zeng, Xiaowei
Tham, Phoebe Huijun
Phua, Fiona Soo Zeng
Cheng, Wei
Zeng, Wenfeng
Shi, Haoran
Mei, Lin
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2019
Source: Chen, H., Zeng, X., Tham, P. H., Phua, F. S. Z., Cheng, W., Zeng, W., ... Zhao, Y. (2019). NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy. Angewandte Chemie International Edition, 7641-7646. doi:10.1002/anie.201900886
Journal: Angewandte Chemie International Edition
Abstract: The co-delivery of photosensitizers with prodrugs sensitive to reactive oxygen species (ROS) for light-triggered ROS generation and cascaded prodrug activation has drawn tremendous attention. However, the absence of a feasible method to deliver the two components at a precise ratio has impaired the application potential. Herein, we report an efficient method to produce a nanosized platform for the delivery of an optimized ratio of the two components by the means of host–guest strategy for maximizing the combination therapy efficacy of cancer treatment. The key features of this host–guest strategy for the combination therapy are that the ratio between photosensitizer and ROS-sensitive prodrug can be easily tuned, near-infrared (NIR) irradiation can sensitize the photosensitizer and activate the paclitaxel prodrug for its release, and the accumulation process can be tracked by NIR imaging to maximize the efficacy of photodynamic and chemotherapy.
URI: https://hdl.handle.net/10356/137650
ISSN: 1433-7851
DOI: 10.1002/anie.201900886
Rights: This is the peer reviewed version of the following article: Chen, H., Zeng, X., Tham, P. H., Phua, F. S. Z., Cheng, W., Zeng, W., ... Zhao, Y. (2019). NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy. Angewandte Chemie International Edition, 7641-7646. doi:10.1002/anie.201900886, which has been published in final form at 10.1002/anie.201900886. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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