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dc.contributor.authorFeitosa, Mary F.en_US
dc.contributor.authorKraja, Aldi T.en_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorSung, Yun J.en_US
dc.contributor.authorWinkler, Thomas W.en_US
dc.contributor.authorNtalla, Ioannaen_US
dc.contributor.authorGuo, Xiuqingen_US
dc.contributor.authorFranceschini, Noraen_US
dc.contributor.authorCheng, Ching-Yuen_US
dc.contributor.authorSim, Xuelingen_US
dc.contributor.authorVojinovic, Dinaen_US
dc.contributor.authorMarten, Jonathanen_US
dc.contributor.authorMusani, Solomon K.en_US
dc.contributor.authorLi, Changweien_US
dc.contributor.authorBentley, Amy R.en_US
dc.contributor.authorBrown, Michael R.en_US
dc.contributor.authorSchwander, Karenen_US
dc.contributor.authorRichard, Melissa A.en_US
dc.contributor.authorNoordam, Raymonden_US
dc.contributor.authorAschard, Huguesen_US
dc.contributor.authorBartz, Traci M.en_US
dc.contributor.authorBielak, Lawrence F.en_US
dc.contributor.authorDorajoo, Rajkumaren_US
dc.contributor.authorFisher, Virginiaen_US
dc.contributor.authorHartwig, Fernando P.en_US
dc.contributor.authorHorimoto, Andrea R. V. R.en_US
dc.contributor.authorLohman, Kurt K.en_US
dc.contributor.authorManning, Alisa K.en_US
dc.contributor.authorRankinen, Tuomoen_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorTajuddin, Salman M.en_US
dc.contributor.authorWojczynski, Mary K.en_US
dc.contributor.authorAlver, Marisen_US
dc.contributor.authorBoissel, Mathildeen_US
dc.contributor.authorCai, Qiuyinen_US
dc.contributor.authorCampbell, Archieen_US
dc.contributor.authorChai, Jin Fangen_US
dc.contributor.authorChen, Xuen_US
dc.contributor.authorDivers, Jasminen_US
dc.contributor.authorGao, Chuanen_US
dc.contributor.authorGoel, Anujen_US
dc.contributor.authorHagemeijer, Yanicken_US
dc.contributor.authorHarris, Sarah E.en_US
dc.contributor.authorHe, Meianen_US
dc.contributor.authorHsu, Fang-Chien_US
dc.contributor.authorJackson, Anne U.en_US
dc.contributor.authorKähönen, Mikaen_US
dc.contributor.authorKasturiratne, Anuradhanien_US
dc.contributor.authorKomulainen, Pirjoen_US
dc.contributor.authorKühnel, Brigitteen_US
dc.contributor.authorLaguzzi, Federicaen_US
dc.contributor.authorLuan, Jian'anen_US
dc.contributor.authorMatoba, Nanaen_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorPadmanabhan, Sandoshen_US
dc.contributor.authorMuhammad Riazen_US
dc.contributor.authorRueedi, Ricoen_US
dc.contributor.authorRobino, Antoniettaen_US
dc.contributor.authorSaid, M. Abdullahen_US
dc.contributor.authorScott, Robert A.en_US
dc.contributor.authorSofer, Tamaren_US
dc.contributor.authorStančáková, Alenaen_US
dc.contributor.authorTakeuchi, Fumihikoen_US
dc.contributor.authorTayo, Bamidele O.en_US
dc.contributor.authorvan der Most, Peter J.en_US
dc.contributor.authorVarga, Tibor V.en_US
dc.contributor.authorVitart, Veroniqueen_US
dc.contributor.authorWang, Yajuanen_US
dc.contributor.authorWare, Erin B.en_US
dc.contributor.authorWarren, Helen R.en_US
dc.contributor.authorWeiss, Stefanen_US
dc.contributor.authorWen, Wanqingen_US
dc.contributor.authorYanek, Lisa R.en_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorZhao, Jing Huaen_US
dc.contributor.authorAfaq, Saimaen_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorAmini, Marzyehen_US
dc.contributor.authorArking, Dan E.en_US
dc.contributor.authorAung, Tinen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorBorecki, Ingriden_US
dc.contributor.authorBroeckel, Ulrichen_US
dc.contributor.authorBrown, Morrisen_US
dc.contributor.authorBrumat, Marcoen_US
dc.contributor.authorBurke, Gregory L.en_US
dc.contributor.authorCanouil, Mickaëlen_US
dc.contributor.authorChakravarti, Aravindaen_US
dc.contributor.authorCharumathi, Sabanayagamen_US
dc.contributor.authorIda Chen, Yii-Deren_US
dc.contributor.authorConnell, John M.en_US
dc.contributor.authorCorrea, Adolfoen_US
dc.contributor.authorde Las Fuentes, Lisaen_US
dc.contributor.authorde Mutsert, Renéeen_US
dc.contributor.authorde Silva, H Janakaen_US
dc.contributor.authorDeng, Xuanen_US
dc.contributor.authorDing, Jingzhongen_US
dc.contributor.authorDuan, Qingen_US
dc.contributor.authorEaton, Charles B.en_US
dc.contributor.authorEhret, Georgen_US
dc.contributor.authorEppinga, Ruben N.en_US
dc.contributor.authorEvangelou, Evangelosen_US
dc.contributor.authorFaul, Jessica D.en_US
dc.contributor.authorFelix, Stephan B.en_US
dc.contributor.authorForouhi, Nita G.en_US
dc.contributor.authorForrester, Terrenceen_US
dc.contributor.authorFranco, Oscar H.en_US
dc.contributor.authorFriedlander, Yechielen_US
dc.contributor.authorGandin, Ilariaen_US
dc.contributor.authorGao, Heen_US
dc.contributor.authorGhanbari, Mohsenen_US
dc.contributor.authorGigante, Brunaen_US
dc.contributor.authorGu, C. Charlesen_US
dc.contributor.authorGu, Dongfengen_US
dc.contributor.authorHagenaars, Saskia P.en_US
dc.contributor.authorHallmans, Göranen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHe, Jiangen_US
dc.contributor.authorHeikkinen, Samien_US
dc.contributor.authorHeng, Chew-Kiaten_US
dc.contributor.authorHirata, Makotoen_US
dc.contributor.authorHoward, Barbara Ven_US
dc.contributor.authorIkram, M. Arfanen_US
dc.contributor.authorJohn, Ulrichen_US
dc.contributor.authorKatsuya, Tomohiroen_US
dc.contributor.authorKhor, Chiea Chuenen_US
dc.contributor.authorKilpeläinen, Tuomas O.en_US
dc.contributor.authorKoh, Woon-Puayen_US
dc.contributor.authorKrieger, José E.en_US
dc.contributor.authorKritchevsky, Stephen B.en_US
dc.contributor.authorKubo, Michiakien_US
dc.contributor.authorKuusisto, Johannaen_US
dc.contributor.authorLakka, Timo A.en_US
dc.contributor.authorLangefeld, Carl D.en_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorLehne, Benjaminen_US
dc.contributor.authorLewis, Cora E.en_US
dc.contributor.authorLi, Yizeen_US
dc.contributor.authorLin, Shiowen_US
dc.contributor.authorLiu, Jianjunen_US
dc.contributor.authorLiu, Jingminen_US
dc.contributor.authorLoh, Marieen_US
dc.contributor.authorLouie, Tinen_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorMcKenzie, Colin A.en_US
dc.contributor.authorMeitinger, Thomasen_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMilaneschi, Yurien_US
dc.contributor.authorMilani, Lilien_US
dc.contributor.authorMohlke, Karen L.en_US
dc.contributor.authorMomozawa, Yukihideen_US
dc.contributor.authorNalls, Mike A.en_US
dc.contributor.authorNelson, Christopher P.en_US
dc.contributor.authorSotoodehnia, Nonaen_US
dc.contributor.authorNorris, Jill M.en_US
dc.contributor.authorO'Connell, Jeff R.en_US
dc.contributor.authorPalmer, Nicholette D.en_US
dc.contributor.authorPerls, Thomasen_US
dc.contributor.authorPedersen, Nancy L.en_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorPeyser, Patricia A.en_US
dc.contributor.authorPoulter, Neilen_US
dc.contributor.authorRaffel, Leslie J.en_US
dc.contributor.authorRaitakari, Olli T.en_US
dc.contributor.authorRoll, Kathrynen_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorRosendaal, Frits R.en_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorSchmidt, Carsten O.en_US
dc.contributor.authorSchreiner, Pamela J.en_US
dc.contributor.authorSchupf, Nicoleen_US
dc.contributor.authorScott, William R.en_US
dc.contributor.authorSever, Peter S.en_US
dc.contributor.authorShi, Yuanen_US
dc.contributor.authorSidney, Stephenen_US
dc.contributor.authorSims, Marioen_US
dc.contributor.authorSitlani, Colleen M.en_US
dc.contributor.authorSmith, Jennifer A.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorStarr, John M.en_US
dc.contributor.authorStrauch, Konstantinen_US
dc.contributor.authorStringham, Heather M.en_US
dc.contributor.authorTan, Nicholas Y. Q.en_US
dc.contributor.authorTang, Huaen_US
dc.contributor.authorTaylor, Kent D.en_US
dc.contributor.authorTeo, Yik Yingen_US
dc.contributor.authorTham, Yih Chungen_US
dc.contributor.authorTurner, Stephen T.en_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorVollenweider, Peteren_US
dc.contributor.authorWaldenberger, Melanieen_US
dc.contributor.authorWang, Lihuaen_US
dc.contributor.authorWang, Ya Xingen_US
dc.contributor.authorWei, Wen Binen_US
dc.contributor.authorWilliams, Christineen_US
dc.contributor.authorYao, Jieen_US
dc.contributor.authorYu, Caizhengen_US
dc.contributor.authorYuan, Jian-Minen_US
dc.contributor.authorZhao, Weien_US
dc.contributor.authorZonderman, Alan B.en_US
dc.contributor.authorBecker, Diane M.en_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorBowden, Donald W.en_US
dc.contributor.authorChambers, John C.en_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorFarrall, Martinen_US
dc.contributor.authorFranks, Paul W.en_US
dc.contributor.authorFreedman, Barry I.en_US
dc.contributor.authorFroguel, Philippeen_US
dc.contributor.authorGasparini, Paoloen_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorJonas, Jost Brunoen_US
dc.contributor.authorKamatani, Yoichiroen_US
dc.contributor.authorKato, Norihiroen_US
dc.contributor.authorKooner, Jaspal Sen_US
dc.contributor.authorKutalik, Zoltánen_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorLaurie, Cathy C.en_US
dc.contributor.authorLeander, Karinen_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorStudy, Lifelines Cohorten_US
dc.contributor.authorMagnusson, Patrik K. E.en_US
dc.contributor.authorOldehinkel, Albertine J.en_US
dc.contributor.authorPenninx, Brenda W. J. H.en_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPorteous, David J.en_US
dc.contributor.authorRauramaa, Raineren_US
dc.contributor.authorSamani, Nilesh J.en_US
dc.contributor.authorScott, Jamesen_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorvan der Harst, Pimen_US
dc.contributor.authorWagenknecht, Lynne E.en_US
dc.contributor.authorWareham, Nicholas J.en_US
dc.contributor.authorWatkins, Hughen_US
dc.contributor.authorWeir, David R.en_US
dc.contributor.authorWickremasinghe, Ananda R.en_US
dc.contributor.authorWu, Tangchunen_US
dc.contributor.authorZheng, Weien_US
dc.contributor.authorBouchard, Claudeen_US
dc.contributor.authorChristensen, Kaareen_US
dc.contributor.authorEvans, Michele K.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHorta, Bernardo L.en_US
dc.contributor.authorKardia, Sharon L. R.en_US
dc.contributor.authorLiu, Yongmeien_US
dc.contributor.authorPereira, Alexandre C.en_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorRidker, Paul M.en_US
dc.contributor.authorvan Dam, Rob M.en_US
dc.contributor.authorGauderman, W. Jamesen_US
dc.contributor.authorZhu, Xiaofengen_US
dc.contributor.authorMook-Kanamori, Dennis O.en_US
dc.contributor.authorFornage, Myriamen_US
dc.contributor.authorRotimi, Charles N.en_US
dc.contributor.authorCupples, L. Adrienneen_US
dc.contributor.authorKelly, Tanika N.en_US
dc.contributor.authorFox, Ervin R.en_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorTai, E. Shyongen_US
dc.contributor.authorWong, Tien Yinen_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorPalmas, Walteren_US
dc.contributor.authorRice, Kennethen_US
dc.contributor.authorMorrison, Alanna C.en_US
dc.contributor.authorElliott, Paulen_US
dc.contributor.authorCaulfield, Mark J.en_US
dc.contributor.authorMunroe, Patricia B.en_US
dc.contributor.authorRao, Dabeeru C.en_US
dc.contributor.authorProvince, Michael A.en_US
dc.contributor.authorLevy, Danielen_US
dc.date.accessioned2020-04-08T03:49:25Z-
dc.date.available2020-04-08T03:49:25Z-
dc.date.issued2018-
dc.identifier.citationFeitosa, M. F., Kraja, A. T., Chasman, D. I., Sung, Y. J., Winkler, T. W., Ntalla, I., . . . Levy, D. (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PloS one, 13(6), e0198166-. doi:10.1371/journal.pone.0198166en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://hdl.handle.net/10356/137674-
dc.description.abstractHeavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.en_US
dc.language.isoenen_US
dc.relation.ispartofPloS oneen_US
dc.rights© 2018 The Author(s) (Public Library of Science). This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.en_US
dc.subjectScience::Medicineen_US
dc.titleNovel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestriesen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1371/journal.pone.0198166-
dc.description.versionPublished versionen_US
dc.identifier.pmid29912962-
dc.identifier.scopus2-s2.0-85049155160-
dc.identifier.issue6en_US
dc.identifier.volume13en_US
dc.subject.keywordsAlcohol Consumptionen_US
dc.subject.keywordsMeta-analysisen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
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